ChromosomenstörungTrisomie 18: What does Edwards syndrome in a baby means

Trisomy 18: What does this chromosomal abnormality to the unborn child and the parents, and making the Edwards syndrome may be caused.

The emergence of a child is a miracle of nature and such a complicated process that it is quite can thereby cause mistakes. If an error occurs in the fusion of genetic material between men and women in the form of egg and sperm cells, may lead to the dreaded chromosome disorders.

The most common chromosomal abnormality is trisomy 21, also known as Down syndrome. However, there are also a number of other chromosomal disorders, which often cause serious distortions in the unborn child. One of them is trisomy 18, which are described in detail here.

 

What is Trisomy 18?

In the trisomy 18 is a chromosomal disorder and thus a severe developmental disorder in an embryo. Is affected the child, is the chromosome 18 instead of three in duplicate in each cell. Most all body cells are affected, often only a few cells are affected.

Chromosomal disorders such as trisomy 21 and trisomy 18 can cause serious birth defects in the unborn child.Chromosomal disorders such as trisomy 21 and trisomy 18 can cause serious birth defects in the unborn child.
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Blonde hair, brown hair, blue or green eyes: The chromosomes carry the genetic information of every person. Normally, each person has 23 pairs of chromosomes, for a total of 46 chromosomes. If a person has more or less chromosomes, is spoken by a genome mutation.

In a trisomy, the excess gene material causes various physical and mental impairment in the child.

Trisomy 18 was discovered in 1960 by British geneticist John Hilton Edwards and therefore by name.

 

How Trisomy 18 affects the baby?

If it comes to a child on the origin of trisomy 18, the baby at birth is severely underweight. The children suffer from severe malformations of the organs, especially the heart, brain, kidneys and gastrointestinal tract can be affected. Also malformations of the hands and feet or the skull may be features of trisomy 18th

 

How old children with trisomy 18?

Is trisomy 18 before the child dies often during pregnancy or in the first months after birth. Few children with trisomy be older than one year, in rare cases they reach adolescence.

 

When will the trisomy 18 is recognizable?

With the means of prenatal diagnosis of trisomy 18 can already be detected during pregnancy. Women aged 35 and over can perform a prenatal chromosomal analysis as a routine investigation.

 

Is trisomy 18 be cured?

No, trisomy 18, unfortunately, is not curable. Depending on how severe the malformation of organs may be possible to help the children affected by operations.

 

How often trisomy 18 before?

To the frequency of trisomy 18, there are several reports in the literature. In live-born children, the probability of trisomy 18 is about 1: 5,000. Girls are affected about 3 times more often than boys. Trisomy 21 occurs much more frequently, of it is statistically affected one of 700 children. The three most common trisomies are the trisomy 21 (Down syndrome), trisomy 13 (Patau syndrome) and trisomy 18 (Edwards syndrome).

 

What causes trisomy 18? Is trisomy 18 hereditary?

There are two different versions of trisomy 18. The free trisomy 18 occurs randomly and is therefore not inheritable. The so-called translocation trisomy 18 is rare - this variant is usually inherited from one parent to the child. With increasing age of the mother, the likelihood of developing a chromosomal abnormality such as trisomy 18. If, in a parent shown to increase before the translocation to chromosome 18, is the probability of inheritance at about 25 percent.

 

How is a trisomy 18?

In the development of a baby cell division known as mitosis and meiosis meiosis also known to play a fundamental role. If there is a bad development, a chromosomal disorder such as trisomy 18 or trisomy 21, also known as Down's syndrome, occur in these processes.

 

Trisomy 18 - until when an abortion is possible?

Under normal circumstances, abortion is tolerated only up to the 12th week of pregnancy in Germany. However, if a medical indication is, therefore, a threat to the physical or mental health of the mother, an abortion of the fetus is legal even after the 13th week of pregnancy. If the mother is not to feel, for example, due to a malformation of the child, such as trisomy 18, trisomy 21, or spina bifida (open spine) able to get the child, a late termination of pregnancy even until shortly before birth is possible ,

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